Tag Archive | science

Let’s Talk Biology Again

I’ve discussed this before, in bits and pieces, here and there, now and again. But perhaps it’s wise to assemble all this under one roof where it can be easily referenced.

Approximately 1 in 15000 females, at birth is XY. They are females with female genitals, the works. XY does not mean male. Of these, 1 in 80,000 is Swyer’s Syndrome, and 1 in 20,000 has complete androgen insensitivity syndrome. Another subset has partial androgen insensitivity syndrome and estimates of those born female vary greatly there, from 1 in 20,000 to 1 in 50,000. The cumulative numbers for these three groups are generally assessed at 1 in 15,000, but the frequency could be even higher. The vast majority of XY females are sterile, but rarely some are not, as documented in this study.

1 in 20000 males at birth is XX, also called de la Chapelle syndrome. They are males with male genitals. XX does not mean female. However, the frequency of XX males where the SRY gene crossed over from the Y chromosome to the X may be even higher than that, as this study suggests SRY gene crossover happens more often than previously suspected.

1 in 600 children is XXY, Klinefelters. For the longest time, doctors assumed XXY were always male, because only XXY males had fertility issues, until some biologists decided to go look. And suddenly they found lots of XXY females. This breakthrough came in the last decade so it is relatively “new” news and not all doctors may have heard this year.

The above situations are all scientific facts and prove, conclusively that sex and gender are not determined solely by 5th grade biology lessons about XX and XY, which were simplified for you because at that point in your life, you couldn’t have handled the complexities involved.

So what determines sex and gender? What sex is a male soldier who loses his legs and genitals to an IED. It’s all gone. He has no testicles, no penis, so what sex is he? Stupid question, isn’t it?

It’s stupid because sex and gender are determined in the brain, specifically in the white matter structures of the brain.

Every fetus starts out female and stays female until week 8. That’s when sexual differentiation begins.

The brain is the first human organ to sexually differentiate. This occurs between weeks 8-16. The fetus doesn’t even have genitals until week 14 and then it’s only the unisex “genital tuber” which will later become clitoris, vagina, labia, or penis, testicles, and scrotum.

What drives sexual differentiation? Not genes. Not XX. Not XY. What drives sexual differentiation in the fetus is hormones. Males develop as male because they received about 4 times as much testosterone as estrogen. Females develop as females because they receive about 5 times as much estrogen as testosterone. This is another scientific fact. Cry about it all you want but this is what creates sex and gender.

Consequently, if the mother, during pregnancy for some reason has hormonal interactions that change the basic hormonal ratios away from the median described above, you can get a child whose brain develops one way then their body develops another. Not enough testosterone in weeks 8-16 then returning to median hormonal ratios for weeks 16 and onward? Transgender child with a female brain and male body. Too much testosterone in weeks 8-16 then returning to median hormonal ratios for weeks 16 and onward? Transgender child with male brain and female body. Here is the American Medical Association’s 2011 Annual Meeting Presentation on how hormonal ratios can vary and thus produce the entire spectrum of LGBT people. The presentation is about 70 minutes long, but informative, so be prepared to sit and listen.

So why not fix the brain? We don’t know how without killing the patient. Further, “fixing” the brain would likely destroy the entire personality of that person, a severe violation of their personal liberty and autonomy. So what do we do? We fix the body, which turns out to be relatively easy.

This is the reality of what being transgender means. And I, for one, am tired of ignorant people not understanding science and trying to impose their small minded bigotry against transgender people.

Educate yourself. The science is all available if you want to understand it. The American Psychological Association, the American Psychiatric Association, the American Medical Association, and the American College of Physicians all support the above statements, and all support social transition, hormonal therapy, and surgery as the proper treatment for being transgender. The AMA supports hormone treatment and surgery for transgender patients. The American Psychiatric Association supports transition related medical care for transgender people.

Those of you who choose to wallow in ignorance and hate are what drive transgender kids to suicide, not being transgender but being hated by small minded bigots like yourselves.

Grow up, and stop hating. And stop claiming 5000 year old superstitions that you call a “bible” are somehow right when compared to science. The rest of us are tired of your narrow minded, childish, and anti-scientific ways of thinking. Transgender women are women. Transgender men are men. Deal with it.

One More Time – The New Brain Study Does NOT Refute Current Neurobiological Models of Being Transgender

I’ve been challenged elsewhere by people about my contention that this new “no female or male brain” does not invalidate the older neurobiological studies that show a neurobiological link to being transgender. I asserted it did not. Others flatly asserted it did.

So, I went directly to Professor Daphna Joel, one of the authors of this study. Below is my query, and below that is the screenshot of her reply.

She agrees with me that this study does not invalidate the neurobiological model of gender identity. Read that again. And then read that again.

LetterToProfJoel

 

Here is here response.

 

LetterFromProfJoel

In fact, she agrees with me that it is very possible that just a few key structures control our sense of gender identity. So the next time some gender critical feminist tries to cite this study and say that being transgender is a “social” phenomenon only, refer them here. The truth is we still do not know, and while the body of evidence is growing, the important point is this study does not invalidate the neurobiological model of why we are transgender.

New Brain Study Reinforces Neurobiological Explanation of Being Transgender

A new brain study was released that shows human brains are a mosaic of male and female structures. A few people have tried to use this study to discredit all the other studies that have identified specific differences in male and female brains, and how transgender people have brains that are more like the gender with which they identify than the gender assigned at birth.

MTF_Brain_Scan_differences

Let’s remember this slide for a moment, ok? Don’t lose sight of this image on this slide.

The new study, The brains of men and women aren’t really that different, study finds, does not say that male and female brains are identical. It says they are extremely similar and that any male or female brain has a large mix of more male or more female structures. In addition, this study looked at the overall brain, at the topology of the total brain to reach its conclusion.

Now interestingly, this study actually reinforces the existing neurobiological research into transgender brains thus far. How can it do that? Because it shows how similar male and female brains are, and what that means is you don’t have to have a “completely female” brain to be an MtF trans woman or a “completely male” brain to be an FtM trans man.

Instead, this study further enhances that it is only a few small critical structures, just like the BSTc in the slide previously that which is tiny! It’s inside the hypothalamus, which itself is about the size of a peanut. And then it’s inside the stria terminalis, which is a small structure inside the hypothalamus itself. And then the difference is in the bed nucleus, which is inside the stria terminalis which is inside that tiny hypothalamus. And we already know from other studies that this region of the brain appears to be linked to gender identity and somewhat also towards sexual orientation.

So the studies done to date do not contradict the neurobiological thesis for being transgender. In fact, this study further enhances that work by showing how small the changes can be that lead one to feeling gender identity dysphoria.

When people try to argue that this study disproves a biological basis for being transgender, refer them to my comments here. This study reinforces the neurobiological model.

I will add here, a diagram from the TED Talk of one of the scientists involved in this study. The brain itself is neither male nor female. It’s always a mosaic of structures. But the mosaic consists of a mixture of male and female structures. And every human brain is like this. So rather than having a “female” brain or a “male” brain, what matters are those few individual structures that control sense of gender identity.

IntersexBrains

A Visit With Dr. Chettawut And Other Random Thoughts

IMAG0099-resizedIt’s Wednesday morning in Bangkok and  I had my final visit with Dr. Chettawut today. He said I am healing “beautifully” so far. We took photos and while I guess I look less than stellar, no makeup and clearly physically tired, I’ll excuse myself with it having been just three weeks since surgery.

My only remaining medication is my antibiotic, which I was told to finish. Judging by what’s left that will be sometime next week.

My dilation schedule with #2 changed this week. That’s the dilator that’s getting most of the time now with #1 just basically helping me to relax and loosen up. Strangely enough, unlike a lot of the other women I’ve met here, my most relaxed session is the morning, and I’m at my tightest in the evening, so that session takes the longest.

I’ve stood a few times looking at myself in the mirror now, both dressed and undressed, both frontal and sideways. I don’t think I’m doing too badly for a woman my age either. And I will admit that I’m starting to see what my daughter must see when she teases me about a bikini next summer.

I recently participated in a long Facebook thread started by a woman who posted publicly (if you don’t want dissenting comments, post for friends only!) about her opposition to transgender protection regulations in a Houston suburb school district. I provided fact after fact, but these people refused to consider these facts, or the professional opinions of the American Psychological Association, the American Psychiatric Association, the American Medical Association, or the American College of Physicians. They refused to accept the scientific research, with one paranoid delusional claiming that science and professional medicine had been taken over by “liberals” and “Satan”. Well, buddy, when you’re that paranoid and delusional, you are the one that needs psychiatric help, not transgender kids. And they refused to accept the criminal evidence provided by the states and major cities that have enacted transgender protection ordinances, again claiming “liberal” conspiracy.

This little discussion was absolute proof that these bigots don’t care about facts. They just twist facts to try to justify their bigotry. They totally lack the compassion, empathy, and love that Christ himself told them to show.

That’s what dealing with transphobic bigots is like. Deny, deny, deny, fall back on “cuz Gawd”. It’s a blatant display of willful scientific and medical ignorance. And they are often proud of it!!! You’re left with a sick sinking feeling that these people are the exact sort that would gladly load cattle cars with human beings just so long as nobody disturbs their comfort. And granting equal rights under the law to transgender people? They just don’t want to. One practically admitted he wanted someone else to mock. These are sick, sick human beings.

In other matters, Tuesday evening (last night), Julie and I went to the Japanese restaurant just outside the Tesco department store about 5 blocks down the street. It was a feast for 950 Baht total (roughly $26). We got the beef and seafood. They put hot coals in the little burner in the center of your table and you cook your meal there, with over half a dozen different seasonings provided. We had more beef than we could eat, plus mega-shrimp, small salmon steaks, and various vegetables we could put on the grill as well. There was also a rice bowl that basically looked like fried rice unstirred, so we stirred that and ate about half of that as well. Julie and I split the salad and it was gone, and we each also got Miso soup with the meal. All in all, I came home stuffed and happy. It as delicious.

Today Julie is at the Tiger Temple. I have her looking for a few things for me for other people, plus I told her I wanted my own stuffed tiger if they’re available. She’ll be gone all day as that trip is 3 hours drive each way north of the city and 4 hours at the temple proper. She’s going to try to sign up for the chance to get a tiger photo where the tiger puts its head in her lap. I hope she gets it! If I can return someday, I want to see the Tiger Temple too, when I am healthier.

Our trip to the other side of the world is drawing to a close. Julie and I will see one of the local temples tomorrow, and maybe one other local sight on Friday. Saturday we rest and pack, as our ride back to the airport comes to the hotel at 9pm that evening and our flight back to the US begins just after midnight. We’ll arrive back in Houston on Sunday, August 16th, at about 8:30 am at international terminal D. I need to help Julie get over to terminal B for her flight home to Memphis that leaves around 10:30 so it will be close. We have to come in through customs, collect luggage, take the train to terminal B, then she has to check in at the counter and check her bag again for the separate flight home. We’ll make it but we’ll be busy. After she’s set, I’ll arrange to meet my ride outside terminal B at the arrivals pick up area. And then home, where the process of settling back in, re-establishing my dilation and massage schedules begins, and where I get comfortable for a week before resuming work on Monday, August 24th.

To all who have helped distract me on this trip, keeping my mind off the difficulties of healing early on, thank you. You have my gratitude for simply being there. But don’t worry. I’m not going away, and as I recover, I do hope to meet more of you who are in and around the Houston area.

Yet Another Reply To Those Who Continue to Demean Transgender People

I won’t comment on whether “transracial identity” is a thing or not except to say this – the only reason conservatives raise this issue is to denigrate transgender people.

The two issues are not comparable. These are not apples and apples, but apples and oranges.

First off, “transracial identity” is a phrase that popped onto the radar of everyone just this week, in relation to one single person who has been living as a black woman for years even though she was born very, very white. Race is a completely social construct. We currently have no biological evidence that race is anything other than a social construct. Prior to this week, the term “transracial” was a clinical term restricted to discussing children of one race being adopted and raised by parents of another race, and any mental health issues that might arise therefrom. Now the word has been appropriated by non-professionals who are know-nothings seeking to create a false comparison between transgender and race as identifying characteristics.

On the other hand, there is a wealth of peer reviewed scientific studies that I have referenced elsewhere that demonstrate that being transgender is exactly what the American Psychiatric Association, American Psychological Association, the American Medical Association, and the American College of Physicians all say it is – a medical condition.

So right off the bat the two things are different. One is not a biological component of self identity so far as we know and the other one, being transgender, is a biological component of self identity, based in white matter brain structures that form and set in a particular gender configuration before birth. Being transgender is recognized as a medical condition and has a standard treatment procedure, often referred to by those within the trans community as “transition”. This treatment procedure and the process of going through it involves hormone therapy, psychological therapy (to deal with the issues of people being assholes, not from being trans itself), and surgeries. “Transracial identity” has no such recognition and no such standard treatment plans.

Therefore why use one, which appears to be about one individual, to compare to the other? I’ll tell you why. Because the behavior of the one individual is seen by many as potentially unstable and disturbed. And comparing the situation of Rachel Dolezal to that of transgender people is an attempt to demean, marginalize, and ostracize transgender people by trying to point out that if Rachel Dolezal is ridiculous then transgender people are ridiculous too.

When you see someone doing this, odds are very high they are someone who has serious issues about transgender people. And they are further also advertising their great big lack of knowledge about the field of transgender studies and treatment today, as well as about human biology. No, Virginia, as I have said before, XX is not female and XY is not male.

And finally, those still arguing that being transgender is a “mental illness” – you are in the deep deep minority among health care professionals in both the mental health care and physical health care arenas.

American Psychiatric Association Position Statement About Transgender Persons

American Psychological Association Position Statement About Transgender Persons

American Medical Association Position Statement About Transgender Persons

American Medical Association 2011 Annual Meeting Webcast Explaining Hormonal In Utero Causes of Being Transgender

American College of Physicians Position Statement About Transgender Persons

Summary of Research About Neurobiological Causes of Being Transgender